gene_symbol
CTLA4
hgnc_id
HGNC:2505
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG1 Fc enables Fcγ receptor-dependent ADCC/ADCP, depleting CTLA-4–expressing T cells (especially intratumoral Tregs) via NK cells/macrophages.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05212922
disease_id_num_tar_ref
5639
drug_id_num_tar_ref
15329