gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR T cells bind CD19 on target cells, form an immune synapse, and induce killing via perforin/granzyme release (and death receptor signaling), leading to apoptosis of CD19-positive cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-cell surface antigen on normal and malignant B cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06430736
disease_id_num_tar_ref
472
drug_id_num_tar_ref
1315