gene_symbol
CEACAM8
hgnc_id
HGNC:1820
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The Y-90–labeled anti-CD66 antibody binds CEACAM8 (CD66b) on granulocytic cells and emits beta radiation that causes DNA double-strand breaks and lethal damage, directly ablating the bound target cells (with some local crossfire effect).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Granulocyte-specific CD66 family member; dominant marrow target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04856215
disease_id_num_tar_ref
5648
drug_id_num_tar_ref
15344