gene_symbol
CEACAM1
hgnc_id
HGNC:1814
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-CD66 (CEACAM) antibody BW250/183 binds CEACAM1 (CD66a) and delivers Yttrium-90 beta radiation to the bound cells, causing DNA damage (double-strand breaks) and cell death, with some crossfire to nearby cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CD66 family member; part of the targeted CEACAM cluster
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04856215
disease_id_num_tar_ref
5648
drug_id_num_tar_ref
15344