gene_symbol
CEACAM5
hgnc_id
HGNC:1817
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
This Y-90–labeled anti-CD66 antibody targets granulocytic/myeloid CD66 antigens (e.g., CEACAM6/8), not CEACAM5 (CEA). Only cells bound by the antibody receive beta radiation and are killed via DNA damage; CEACAM5+ cells are not targeted.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CD66 family member; recognized by some anti-CD66 clones within the CEACAM cluster
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04856215
disease_id_num_tar_ref
5648
drug_id_num_tar_ref
15344