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gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds HER2 on tumor cells and engages FcγR-bearing immune cells (e.g., NK cells) to trigger antibody-dependent cellular cytotoxicity, killing HER2+ cells; also may activate complement and inhibit HER2 signaling.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain subdomain IV of HER2; IgG1 Fc mediates ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05698186
disease_id_num_tar_ref
5663
drug_id_num_tar_ref
15382