gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Pertuzumab binds HER2 and both blocks HER2 dimerization/signaling (triggering growth inhibition and apoptosis) and engages immune effectors via its Fc to mediate ADCC against HER2-expressing cells.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular subdomain II (dimerization interface), blocking HER2 homo-/heterodimerization (notably with HER3)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05698186
disease_id_num_tar_ref
5663
drug_id_num_tar_ref
15383