gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells recognize the EBV peptide–HLA-A*02:01 complex via their TCR and kill target cells through cytotoxic T-cell mechanisms, primarily perforin/granzyme-mediated apoptosis (with possible Fas/FasL contributions).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Class I peptide–HLA complex; viral (EBV) peptide; restriction allele HLA-A*02:01
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06119256
disease_id_num_tar_ref
5665
drug_id_num_tar_ref
15390