gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CD16a (FcγRIIIa) on NK cells/macrophages binds the Fc of obinutuzumab to mediate ADCC/phagocytosis against CD20+ B cells; the CD16a-expressing effector cells are not targeted or killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated binding; enhanced ADCC via afucosylated Fc
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05845762
disease_id_num_tar_ref
5674
drug_id_num_tar_ref
15411