gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
After ADC delivery to Trop-2–positive cells, the SN-38 payload inhibits topoisomerase I by stabilizing Topo I–DNA complexes, causing DNA damage, S-phase arrest, and apoptosis (with possible bystander effect).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
SN-38 stabilizes Top1–DNA cleavage complexes (Top1 poison)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06356519
disease_id_num_tar_ref
479
drug_id_num_tar_ref
1330