gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
HER2-targeted adoptive NK cells recognize HER2+ tumor cells and kill them via NK cytotoxicity, including perforin/granzyme release and death-receptor (e.g., Fas/TRAIL) pathways.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface overexpression on HER2+ tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05678205
disease_id_num_tar_ref
5679
drug_id_num_tar_ref
15417