gene_symbol
MSLN
hgnc_id
HGNC:7371
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR T cells bind mesothelin on target cells, become activated, and kill them via perforin/granzyme-mediated cytolysis (and death-receptor pathways).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CAR binder (alpaca VHH; CD28/CD3ζ signaling)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06248697
disease_id_num_tar_ref
5682
drug_id_num_tar_ref
15424