gene_symbol
TNFRSF17
hgnc_id
HGNC:11913
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
BCMA-expressing cells are recognized by anti-BCMA CAR-T cells, which upon engagement are activated to kill targets via perforin/granzyme-mediated cytolysis (and Fas/FasL, cytokines), depleting BCMA+ tumor and normal plasma cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor on plasma cells; primary target on malignant and normal BCMA+ plasma cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05698303
disease_id_num_tar_ref
5684
drug_id_num_tar_ref
15429