gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds HER2 and is internalized; lysosomal release of MMAE inhibits microtubules, causing G2/M arrest and apoptosis. The IgG1 Fc can also recruit immune effector cells for ADCC.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC antigen; receptor tyrosine kinase
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06278870
disease_id_num_tar_ref
5685
drug_id_num_tar_ref
15430