gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Disitamab vedotin binds HER2, is internalized, and releases MMAE, which binds beta-tubulin to disrupt microtubules causing G2/M arrest and apoptosis. Beta-tubulin is not the cell-surface target; only HER2+ cells are directly targeted for payload delivery.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
payload (MMAE) target; microtubule polymerization inhibitor
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06278870
disease_id_num_tar_ref
5685
drug_id_num_tar_ref
15430