gene_symbol
KRAS
hgnc_id
HGNC:6407
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR T cells recognize the HLA-A*11:01–presented KRAS G12V peptide on tumor cells, activating cytotoxic T cells to kill via perforin/granzyme-mediated apoptosis (± Fas/FasL).
enzyme_product
On
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Recognition of KRAS G12V peptide presented by HLA-A*11:01 as a peptide–MHC complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06043713
disease_id_num_tar_ref
5689
drug_id_num_tar_ref
15445