gene_symbol
CD22
hgnc_id
HGNC:1643
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD22 ADC binds CD22 on B cells, is internalized, and releases calicheamicin intracellularly, which binds DNA and causes double‑strand breaks leading to apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface B-lineage receptor; mediates internalization of the ADC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06476665
disease_id_num_tar_ref
480
drug_id_num_tar_ref
1331