gene_symbol
NTRK2
hgnc_id
HGNC:8032
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Entrectinib is a small‑molecule TKI that inhibits TRKB (NTRK2) kinase activity, blocking downstream MAPK/PI3K survival signaling and inducing apoptosis of TRKB‑driven tumor cells (e.g., NTRK fusions).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
receptor tyrosine kinase (TrkB); often activated by NTRK2 gene fusions
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05862285
disease_id_num_tar_ref
5703
drug_id_num_tar_ref
15497