gene_symbol
ROS1
hgnc_id
HGNC:10261
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Entrectinib directly inhibits the ROS1 tyrosine kinase in ROS1-driven tumor cells, blocking MAPK/PI3K signaling and inducing apoptosis.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
receptor tyrosine kinase; often activated by ROS1 gene fusions
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05862285
disease_id_num_tar_ref
5703
drug_id_num_tar_ref
15497