gene_symbol
TNF
hgnc_id
HGNC:11892
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
By binding transmembrane TNF-α on activated immune cells, infliximab’s IgG1 Fc triggers ADCC and complement-dependent cytotoxicity and can induce reverse-signaling apoptosis in tmTNF-α–expressing cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds and neutralizes both soluble and transmembrane forms
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05813860
disease_id_num_tar_ref
5724
drug_id_num_tar_ref
15557