gene_symbol
TNF
hgnc_id
HGNC:11892
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Infliximab binds transmembrane TNF on target cells; its IgG1 Fc mediates ADCC and complement-dependent cytotoxicity, and tmTNF reverse signaling can induce apoptosis of activated TNF+ T cells/monocytes.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
transmembrane (tmTNF)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06604728
disease_id_num_tar_ref
5735
drug_id_num_tar_ref
15591