gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CD19-directed CAR T cells bind CD19 on B cells, activate via CD3ΞΆ/costimulatory signaling, and kill targets through perforin/granzyme-mediated cytolysis (and cytokine/death-receptor pathways), causing apoptosis of CD19+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-cell surface antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06307600
disease_id_num_tar_ref
481
drug_id_num_tar_ref
1332