gene_symbol
PVRL4
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds nectin-4 on tumor cells, is internalized, and a cleavable linker releases a topoisomerase I inhibitor that blocks DNA replication, leading to cell-cycle arrest and apoptosis of nectin-4–expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Tumor-associated cell-surface antigen; IgG1 ADC binds and internalizes via nectin-4
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06547736
disease_id_num_tar_ref
485
drug_id_num_tar_ref
1339