gene_symbol
CD274
hgnc_id
HGNC:17635
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Avelumab binds PD-L1 on target cells and, via its IgG1 Fc, engages FcγR on NK cells/macrophages to trigger antibody-dependent cellular cytotoxicity (ADCC), killing PD-L1–expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks PD-L1 interactions with PD-1 and CD80; Fc-competent IgG1 can mediate ADCC via Fcγ receptors.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05574504
disease_id_num_tar_ref
5757
drug_id_num_tar_ref
15647