gene_symbol
TNFRSF17
hgnc_id
HGNC:11913
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds BCMA, is internalized, and releases MMAF to inhibit tubulin, causing G2/M arrest and apoptosis; afucosylated Fc also triggers ADCC/ADCP.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Membrane TNF receptor superfamily member on plasma/myeloma cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05065047
disease_id_num_tar_ref
5762
drug_id_num_tar_ref
15658