gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds BCMA (not beta‑tubulin), is internalized, then releases MMAF that binds the beta‑tubulin vinca domain to inhibit microtubule polymerization, causing G2/M arrest and apoptosis; Fc can also trigger ADCC/ADCP after BCMA binding.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Auristatin payload (MMAF) binds β-tubulin at the vinca site to inhibit microtubule polymerization; affects multiple β-tubulin isoforms
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05065047
disease_id_num_tar_ref
5762
drug_id_num_tar_ref
15658