gene_symbol
MAGEA4
hgnc_id
HGNC:6802
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells recognize the HLA-A2–restricted MAGE-A4 peptide–HLA complex on target cells and kill them via cytotoxic T-cell effector functions (perforin/granzyme-mediated apoptosis, plus Fas–FasL).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Recognized only when presented by HLA-A*02:01; peptide referred to as C1032 in NCI description
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06113315
disease_id_num_tar_ref
5767
drug_id_num_tar_ref
15671