gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Afamitresgene autoleucel TCR-T cells kill only cells presenting the MAGE-A4 peptide in HLA-A2 via T-cell cytotoxicity (perforin/granzyme). HLA-A2 expression alone is not sufficient for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
TCR binds the MAGE-A4 peptide–HLA-A*02:01 complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06113315
disease_id_num_tar_ref
5767
drug_id_num_tar_ref
15671