gene_symbol
CTAG1B
hgnc_id
HGNC:2491
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR T cells recognize NY-ESO-1 peptide–HLA complexes on tumor cells and directly kill them via CTL mechanisms (perforin/granzyme and Fas–FasL apoptosis).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Recognizes NY-ESO-1 157–165 peptide (SLLMWITQC) presented by HLA-A*02:01 (peptide–HLA complex).
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06113315
disease_id_num_tar_ref
5767
drug_id_num_tar_ref
15672