gene_symbol
CTAG2
hgnc_id
HGNC:2492
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Autologous TCR-engineered T cells recognize LAGE-1/NY-ESO-1 peptide–HLA complexes on tumor cells and induce CTL-mediated killing via perforin/granzyme and apoptosis pathways.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Cross-reactive recognition of LAGE-1 peptides presented by HLA-A*02:01 (e.g., LAGE-1a epitope).
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06113315
disease_id_num_tar_ref
5767
drug_id_num_tar_ref
15672