gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The D2C7 scFv binds EGFRvIII on tumor cells, the PE38 exotoxin is internalized and ADP‑ribosylates EF2, blocking protein synthesis and inducing apoptotic cell death (KDEL enhances intracellular retention).
enzyme_product
Off
epitope
On
variant
On
isoform
On
hla_specific
Off
gated
Off
other_modifier
Extracellular neoepitope created by deletion of exons 2–7; targeted by D2C7 scdsFv
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05734560
disease_id_num_tar_ref
5775
drug_id_num_tar_ref
15685