gene_symbol
EEF2
hgnc_id
HGNC:3214
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
D2C7-IT binds EGFR/EGFRvIII on tumor cells, is internalized, and its PE toxin ADP-ribosylates EF2 to block protein synthesis and kill the cell. EF2 is not the recognition target; EF2-expressing cells are killed only if they first bind the drug via EGFR/EGFRvIII.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADP-ribosylation by Pseudomonas exotoxin A (PE38KDEL) inhibits protein synthesis
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05734560
disease_id_num_tar_ref
5775
drug_id_num_tar_ref
15685