gene_symbol
GPC3
hgnc_id
HGNC:4451
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
DNA vaccine induces GPC3-specific CD8+ T cells that recognize GPC3 peptides on MHC I of tumor cells and kill them via perforin/granzyme-mediated cytolysis (with CD4+ T-cell help).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Tumor-associated antigen; GPI-anchored heparan sulfate proteoglycan; overexpressed in HCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06088459
disease_id_num_tar_ref
5779
drug_id_num_tar_ref
15695