gene_symbol
CLDN18
hgnc_id
HGNC:2039
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds CLDN18.2 on target cells, is internalized, and releases a topoisomerase I inhibitor that blocks DNA replication, causing cell-cycle arrest and apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
A2 isoform of claudin-18; tumor-associated cell-surface antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06547736
disease_id_num_tar_ref
485
drug_id_num_tar_ref
1340