gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Autologous TILs recognize the neoantigen–HLA class I complex via their endogenous TCRs and directly kill target cells through perforin/granzyme-mediated cytolysis and Fas–FasL–induced apoptosis, with proinflammatory cytokines aiding.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Recognized by CD8+ TIL TCRs; autologous, polyclonal repertoire
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06473961
disease_id_num_tar_ref
5798
drug_id_num_tar_ref
15744