gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Talquetamab crosslinks CD3 on T cells to GPRC5D on myeloma cells, activating T cells to release perforin/granzymes and kill GPRC5D+ tumor cells; CD3+ T cells are not the lytic target.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Part of the CD3 T-cell receptor complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06550895
disease_id_num_tar_ref
5803
drug_id_num_tar_ref
15755