gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD19 CAR-T cells bind CD19 on B-lineage cells, form an immune synapse, and induce cytotoxicity via perforin/granzyme release (and Fas–FasL apoptosis), leading to target cell death.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Surface antigen on B cells and plasmablasts; extracellular domain binding by CAR scFv
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05828212
disease_id_num_tar_ref
5809
drug_id_num_tar_ref
15765