gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Cetuximab binds EGFR on target cells and engages FcγR-bearing effector cells (e.g., NK cells) to induce antibody-dependent cellular cytotoxicity (± complement), killing EGFR-positive cells; signaling blockade is mainly antiproliferative.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain to block ligand binding and receptor dimerization; mediates ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06534762
disease_id_num_tar_ref
5812
drug_id_num_tar_ref
15775