gene_symbol
IL5RA
hgnc_id
HGNC:6017
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Benralizumab binds IL-5Rα on eosinophils/basophils and engages FcγRIIIa on NK cells to drive potent antibody-dependent cellular cytotoxicity (ADCC), leading to apoptosis/depletion of IL-5Rα+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Alpha chain of IL-5 receptor on eosinophils/basophils; blocks IL-5 signaling
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05734339
disease_id_num_tar_ref
5816
drug_id_num_tar_ref
15801