gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD38 IgG1 binds CD38 and induces complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC) via Fc-engaged NK cells, antibody-dependent cellular phagocytosis (ADCP) by myeloid cells, and can trigger apoptosis of CD38+ cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface ectoenzyme (NADase/ADP-ribosyl cyclase), type II transmembrane glycoprotein
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04972942
disease_id_num_tar_ref
5818
drug_id_num_tar_ref
15804