gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Cetuximab binds EGFR on target cells and its IgG1 Fc engages Fcγ receptors on NK cells/macrophages to induce ADCC (and sometimes CDC), leading to lysis of EGFR+ cells; EGFR blockade also causes antiproliferative effects.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular domain; blocks ligand binding and receptor dimerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05962502
disease_id_num_tar_ref
5831
drug_id_num_tar_ref
15832