gene_symbol
CLDN18
hgnc_id
HGNC:2039
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CLDN18.2 antibody binds CLDN18.2 on tumor cells and triggers Fc-mediated ADCC by effector cells and complement-dependent cytotoxicity (CDC), leading to lysis of CLDN18.2-positive cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
Isoform 2 (gastric) of claudin-18
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05632939
disease_id_num_tar_ref
5833
drug_id_num_tar_ref
15843