gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds CD20 on B cells; afucosylated Fc engages FcγRIIIa on effector cells to mediate potent ADCC and ADCP, and the antibody itself induces direct, caspase‑independent cell death of CD20+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II CD20 binding on B cells; extracellular domain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06547944
disease_id_num_tar_ref
5834
drug_id_num_tar_ref
15850