gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds HER2 via trastuzumab, is internalized, and releases deruxtecan (DXd), a topoisomerase I inhibitor that causes DNA damage and apoptosis; Fc-mediated ADCC also contributes. Membrane-permeable payload enables bystander killing.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Target of the trastuzumab antibody component; cell-surface receptor tyrosine kinase; mediates ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05408845
disease_id_num_tar_ref
5848
drug_id_num_tar_ref
15877