gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
After HER2 binding and internalization, the ADC releases deruxtecan, which inhibits DNA topoisomerase I, causing DNA damage, replication arrest, and apoptosis; the membrane-permeable payload can also diffuse to kill nearby cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Target of the deruxtecan (DXd) payload; enzyme inhibition after internalization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05408845
disease_id_num_tar_ref
5848
drug_id_num_tar_ref
15877