gene_symbol
DLL3
hgnc_id
HGNC:2909
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Bispecific T-cell engager binds DLL3 on tumor cells and CD3 on T cells, creating an immune synapse that activates cytotoxic T cells to kill DLL3-positive cells via perforin/granzyme-mediated lysis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
tumor-associated antigen on SCLC cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06211036
disease_id_num_tar_ref
5849
drug_id_num_tar_ref
15878