gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Sacituzumab govitecan targets Trop-2 on tumor cells, is internalized, and releases SN-38; SN-38 inhibits topoisomerase I, causing DNA breaks and apoptosis (with potential bystander effect). It does not bind DNA topoisomerase I as a targeting antigen.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Intracellular enzymatic target of SN-38 payload; stabilization of TOP1–DNA cleavage complexes
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06682728
disease_id_num_tar_ref
5853
drug_id_num_tar_ref
15887