gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-engineered NK cells bind the target antigen and directly kill antigen-expressing cells via NK effector mechanisms (perforin/granzyme-mediated cytolysis, apoptosis) upon CAR activation.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Target antigen not disclosed in the clinical trial; CAR is described to recognize a disease-relevant cell-surface antigen on pathogenic immune cells.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06468683
disease_id_num_tar_ref
5857
drug_id_num_tar_ref
15901