gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG1 anti-EGFR antibody binds EGFR on target cells and its Fc engages Fcγ receptors on NK cells/macrophages to mediate ADCC (and some CDC), leading to lysis/apoptosis of EGFR+ cells; signaling blockade is antiproliferative.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain to block ligand binding and receptor activation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06259721
disease_id_num_tar_ref
5865
drug_id_num_tar_ref
15922