gene_symbol
CD47
hgnc_id
HGNC:1682
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Blocking CD47–SIRPα lifts the anti-phagocytic signal, enabling macrophage activation and antibody-dependent cellular phagocytosis of CD47-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks CD47-SIRPA interaction (innate immune checkpoint)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06008405
disease_id_num_tar_ref
5872
drug_id_num_tar_ref
15939